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    Background & Aims: The aim of the current study was to investigate the effectiveness of coping-therapy on the well-being of mothers with disabled offspring.   Materials & Methods : This quasi-experimental study included all volunteer mothers with disabled children referring to Saadatabad education center 21 mothers entered the intervention group, and 20 to the control group. The data were gathered through coping strategies questionnaire and personal wellbeing indicator before treatment sessions. They had an eight session coping therapy intervention and then completed post-tests. The data were analyzed statistically.   Results : The results suggested that the mothers' wellbeing did not significantly improve in intervention group. Furthermore, the escape-avoidance strategy and confrontation coping mechanisms respectively decreased and increased. No other changes in coping mechanisms were found as a result of being under coping therapy intervention. In addition, positive correlations were found between social support seeking, self-control, responsibility, and wellbeing.   Conclusion : It seems that coping therapy does not directly lead to wellbeing enhancement however, it affects the coping mechanisms of mothers and in long-term it will result in the wellbeing improvements.   Source: Urmia Med J 2011: 22(5): 493 ISSN: 1027-3727